Discovering and Confronting Bias Head on in Behavioural Neuroscience – My PhD Experience

Abstract

In 2017, I began a PhD in nutritional neuroscience aiming to investigate how high-fat diets impaired cognition, using dietary and behaviour experiments in mice. During the first few months of my PhD, I was aiming to replicate the finding that high-fat diets do in fact impair some types of memory in mice, which should have been an easy task. At first, my results looked ideal, but I had performed them unblinded to dietary group, and I had an inkling this was a problem. Despite this being perceived as a waste of time, I measured and plotted blinded scores – and my ideal results vanished. When considering possible next steps, it was suggested that the best thing for my PhD would be to repeat the experiment until I successfully replicated it, and could proceed from there. This was not the approach I took. This talk discusses how I confronted an issue in my own research, and used it to shape my future research trajectory. I discuss my experiences learning about reproducibility in research, how I tried to use my own experience and my learnings to inform and guide other researchers, and why I ultimately transitioned into a career in meta-research, leaving behind bench research for good.