The Biology of Mongolism
DOI:
https://doi.org/10.2218/resmedica.v3i3.395Abstract
Based on a Dissertation read before the Royal Medical Society on Friday. 2nd March, 1962.
Mongolism is a neuro-endocrine disorder, based on a molecular disturbance, which is manifested by a chromosome abnormality. The mental defect is probably due not specifically to a gene or gene complexes on the chromosomes but to a generalised imbalance of the chromosome set as a result of aneuploidy.
There are three types of chromosome abnormality which have so far been described in mongols
1. Non-disjunction.
2. Translocation.
3. Mosaics.
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