ZAC in GtoPdb v.2023.1

Abstract

The zinc-activated channel (ZAC, nomenclature as agreed by the NC-IUPHAR Subcommittee for the Zinc Activated Channel) is a member of the Cys-loop family that includes the nicotinic ACh, 5-HT₃, GABA_A and strychnine-sensitive glycine receptors [2, 3, 5]. The channel is likely to exist as a homopentamer of 4TM subunits that form an intrinsic cation selective channel equipermeable to Na⁺, K⁺ and Cs⁺, but impermeable to Ca²⁺ and Mg²⁺ [5]. ZAC displays constitutive activity that can be blocked by tubocurarine, TTFB and high concentrations of Ca²⁺ [5]. Although denoted ZAC, the channel is more potently activated by H⁺ and Cu²⁺, with greater and lesser efficacy than Zn²⁺, respectively [5]. Orthologs of the human ZACN gene are present in a wide range of mammalian genomes, but notably not in the mouse or rat genomes. [2, 3].