Neuropeptide S receptor in GtoPdb v.2023.1

Girolamo Caló; Olivier Civelli; Rainer K. Reinscheid; Chiara Ruzza

doi:10.2218/gtopdb/F44/2023.1

Neuropeptide S receptor in GtoPdb v.2023.1

Authors

Girolamo Caló University of Padova
Olivier Civelli University of California, Irvine
Rainer K. Reinscheid University Hospital Jena
Chiara Ruzza University of Ferrara https://orcid.org/0000-0003-1360-202X

DOI:

https://doi.org/10.2218/gtopdb/F44/2023.1

Abstract

The neuropeptide S receptor (NPS receptor) responds to the 20 amino-acid peptide neuropeptide S derived from a precursor (NPS, P0C0P6). NPS activates its receptor at low nanomolar concentrations elevating intracellular cAMP and calcium levels [71]. Currently, some peptidic and small molecule NPS receptor antagonists are available as research tools [27, 79, 8, 59]. No NPS receptor ligands are currently used clinically.