Glycoprotein hormone receptors in GtoPdb v.2023.1

Authors

  • Sabine Costagliola Université Libre de Bruxelles
  • James A. Dias New York State Department of Health
  • Marvin Gershengorn National Institutes of Health
  • Adam J Pawson The University of Edinburgh https://orcid.org/0000-0003-2280-845X
  • Deborah L. Segaloff University of Iowa
  • Axel P.N. Themmen Erasmus University Medical Cente
  • Gilbert Vassart Université Libre de Bruxelles

DOI:

https://doi.org/10.2218/gtopdb/F30/2023.1

Abstract

Glycoprotein hormone receptors (provisional nomenclature [47]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [122, 31].

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Published

26-Apr-2023

Issue

Vol. 2023 No. 1 (2023)

Section

Summaries

How to Cite

“Glycoprotein hormone receptors in GtoPdb v.2023.1” (2023) IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi:10.2218/gtopdb/F30/2023.1.