Complement peptide receptors in GtoPdb v.2023.1

Antonia Cianciulli; Liam Coulthard; Owen Hawksworth; John D. Lee; Xaria X. Li; Vincenzo Mitolo; Peter Monk; Maria A. Panaro; Trent M. Woodruff

doi:10.2218/gtopdb/F5/2023.1

Authors

Antonia Cianciulli University of Bari
Liam Coulthard University of Queensland
Owen Hawksworth University of Queensland
John D. Lee University of Queensland https://orcid.org/0000-0002-9976-7396
Xaria X. Li The University of Queensland https://orcid.org/0000-0001-5924-2977
Vincenzo Mitolo University of Bari
Peter Monk Sheffield University Medical School https://orcid.org/0000-0003-4637-3059
Maria A. Panaro University of Bari
Trent M. Woodruff University of Queensland https://orcid.org/0000-0003-1382-911X

DOI:

https://doi.org/10.2218/gtopdb/F5/2023.1

Abstract

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [113]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3a receptor, C5a receptor 1 and C5a receptor 2), causing cell recruitment and triggering cellular degranulation that contributes to local inflammation.

Complement peptide receptors in GtoPdb v.2023.1

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