5-Hydroxytryptamine receptors in GtoPdb v.2023.1

Authors

  • Rodrigo Andrade Wayne State University https://orcid.org/0000-0002-3969-7840
  • Nicholas M. Barnes University of Birmingham
  • Gordon Baxter Pharmagene Laboratories
  • Joel Bockaert Wayne State University
  • Theresa Branchek Synaptic Pharmaceutical Corporation
  • Amy Butler University of Birmingham
  • Marlene L. Cohen Lilly Research Laboratories
  • Aline Dumuis Université de Montpellier
  • Richard M. Eglen PerkinElmer
  • Manfred Göthert Universität Bonn
  • Mark Hamblin Puget Sound Geriatric Research Education and Clinical Center
  • Michel Hamon Sorbonne Université
  • Paul R. Hartig DuPont-Merck Pharmaceutical Company
  • René Hen Columbia University
  • Julie Hensler University of Texas
  • Katharine Herrick-Davis Albany Medical College
  • Rebecca Hills University of Edinburgh
  • Daniel Hoyer University of Melbourne https://orcid.org/0000-0002-1405-7089
  • Patrick P. A. Humphrey University of Cambridge
  • Klaus Peter Latté Axxonis Pharma AG
  • Luc Maroteaux Sorbonne University https://orcid.org/0000-0002-9499-8603
  • Graeme R. Martin Discovery-Insight
  • Derek N. Middlemiss GlaxoSmithKline
  • Ewan Mylecharane University of Sydney
  • John Neumaier University of Washington
  • Stephen J. Peroutka PPD Pharmaceuticals
  • John A. Peters University of Dundee https://orcid.org/0000-0002-4277-4245
  • Bryan Roth University of North Carolina
  • Pramod R. Saxena Erasmus Universiteit Rotterdam
  • Trevor Sharp University of Oxford
  • Andrew Sleight Hoffman-La Roche
  • Carlos M. Villalon Cinvestav
  • Frank Yocca Bristol-Myers Squibb

DOI:

https://doi.org/10.2218/gtopdb/F1/2023.1

Abstract

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 491]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [471, 387]).

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Published

26-Apr-2023

Issue

Vol. 2023 No. 1 (2023)

Section

Summaries

How to Cite

“5-Hydroxytryptamine receptors in GtoPdb v.2023.1” (2023) IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi:10.2218/gtopdb/F1/2023.1.