Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2

Authors

  • Stephanie Annett RCSI, University of Medicine and Health Sciences
  • Tracy Robson RCSI, University of Medicine and Health Sciences

DOI:

https://doi.org/10.2218/gtopdb/F845/2021.2

Abstract

Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [59], and family members have been targetted for immunosuppressant effects.

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Published

25-Jun-2021

Issue

Vol. 2021 No. 2 (2021)

Section

Summaries

How to Cite

“Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2” (2021) IUPHAR/BPS Guide to Pharmacology CITE, 2021(2). doi:10.2218/gtopdb/F845/2021.2.