Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Antonia Cianciulli; Liam Coulthard; Owen Hawksworth; John D. Lee; Xiang X. Li; Vincenzo Mitolo; Peter Monk; Maria A. Panaro; Trent M. Woodruff

doi:10.2218/gtopdb/F5/2020.5

Authors

Antonia Cianciulli University of Bari
Liam Coulthard University of Queensland
Owen Hawksworth University of Queensland
John D. Lee University of Queensland https://orcid.org/0000-0002-9976-7396
Xiang X. Li The University of Queensland
Vincenzo Mitolo University of Bari
Peter Monk Sheffield University Medical School https://orcid.org/0000-0003-4637-3059
Maria A. Panaro University of Bari
Trent M. Woodruff University of Queensland https://orcid.org/0000-0003-1382-911X

DOI:

https://doi.org/10.2218/gtopdb/F5/2020.5

Abstract

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

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