Glycoprotein hormone receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Sabine Costagliola Université Libre de Bruxelles
  • James A. Dias New York State Department of Health
  • Marvin Gershengorn National Institutes of Health
  • Adam J. Pawson The University of Edinburgh https://orcid.org/0000-0003-2280-845X
  • Deborah L. Segaloff University of Iowa
  • Axel P.N. Themmen Erasmus University Medical Cente
  • Gilbert Vassart Université Libre de Bruxelles

DOI:

https://doi.org/10.2218/gtopdb/F30/2020.4

Abstract

Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].

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Published

24-Sep-2020

How to Cite

Costagliola, S. (2020) “Glycoprotein hormone receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2020(4). doi: 10.2218/gtopdb/F30/2020.4.

Issue

Vol. 2020 No. 4 (2020)

Section

Summaries