Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Annie Beuve Rutgers University
  • Peter Brouckaert Vlaams Instituut voor Biotechnologie
  • John C. Burnett, Jr. Mayo Clinic
  • Andreas Friebe Universität Würzburg
  • John Garthwaite University College London
  • Adrian J. Hobbs Queen Mary University of London
  • Doris Koesling Ruhr-Universität Bochum
  • Michaela Kuhn Physiologisches Institut der Universität Würzburg
  • Lincoln R. Potter University of Minnesota
  • Michael Russwurm Ruhr University Bochum
  • Harald H.H.W. Schmidt Maastricht University
  • Johannes-Peter Stasch Bayer AG
  • Scott A. Waldman Thomas Jefferson University

DOI:

https://doi.org/10.2218/gtopdb/F1022/2020.3

Abstract

The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.

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Published

19-Jun-2020

Issue

Vol. 2020 No. 3 (2020)

Section

Summaries

How to Cite

“Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database” (2020) IUPHAR/BPS Guide to Pharmacology CITE, 2020(3). doi:10.2218/gtopdb/F1022/2020.3.