Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Mohammed Alqinyah University of Georgia
  • Christopher Bodle University of Iowa
  • Josephine Bou Dagher University of Georgia
  • Bandana Chakravarti University of Iowa
  • Shreoshi P. Choudhuri University of Texas Southwestern Medical Center
  • Kirk M. Druey National Institutes of Health
  • Rory A. Fisher University of Iowa
  • Kyle J. Gerber Emory University
  • John R. Hepler Emory University
  • Shelley B. Hooks University of Georgia
  • Havish S. Kantheti University of Texas Southwestern Medical Center
  • Behirda Karaj Michigan State University
  • Jae-Kyung Lee University of Georgia
  • Zili Luo University of Iowa
  • Kirill Martemyanov Scripps Research Institute
  • Luke D. Mascarenhas University of Texas Southwestern Medical Center
  • Hoa Phan Thi Nhu Michigan State University
  • David L. Roman University of Iowa
  • Vincent Shaw Michigan State University
  • Benita Sjögren Purdue University https://orcid.org/0000-0003-1460-1045
  • Katherine E. Squires Emory University
  • Laurie Sutton Scripps Research Institute
  • Thomas M. Wilkie University of Texas Southwestern Medical Center https://orcid.org/0000-0002-9357-637X
  • Keqiang Xie Scripps Research Institute
  • Yalda Zolghadri University of Texas Southwestern Medical Center

DOI:

https://doi.org/10.2218/gtopdb/F891/2019.4

Abstract

Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [29, 419, 418], leading to a termination of GPCR signalling. Interactions through protein:protein interactions of many RGS proteins have been identified for targets other than heteromeric G proteins. Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families. Many of these proteins have been identified to have effects other than through targetting G proteins. Included here is RGS4 for which a number of pharmacological inhibitors have been described.

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Published

16-Sep-2019

Issue

Vol. 2019 No. 4 (2019)

Section

Summaries

How to Cite

“Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database” (2019) IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/F891/2019.4.