Chemerin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Abstract

Nomenclature for the chemerin receptors is presented as recommended by NC-IUPHAR [14, 41]). The chemoattractant protein and adipokine, chemerin, has been shown to be the endogenous ligand for both chemerin family receptors. Chemerin₁ was the founding family member, and when GPR1 was de-orphanised it was re-named Chermerin₂ [41]. Chemerin₁ is also activated by the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1), which is formed via the sequential metabolism of EPA by aspirin-modified cyclooxygenase and lipoxygenase [2, 3]. In addition, two GPCRs for resolvin D1 (RvD1) have been identified: FPR2/ALX, the lipoxin A₄ receptor, and GPR32, an orphan receptor [43].