Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Bernard Attali Tel Aviv University https://orcid.org/0000-0003-1066-7047
  • K. George Chandy University of California Irvine
  • M. Hunter Giese Columbia University
  • Stephan Grissmer Ulm University
  • George A. Gutman University of California Irvine
  • Lily Y. Jan University of California San Francisco
  • Michel Lazdunski CNRS Valbonne
  • David Mckinnon State University of New York at Stony Brook
  • Jeanne Nerbonne Washington University
  • Luis A. Pardo Max Planck Institute for Experimental Medicine
  • Gail A. Robertson University of Wisconsin-Madison
  • Bernardo Rudy New York University
  • Michael C. Sanguinetti University of Utah
  • Walter Stühmer Max Planck Institute for Experimental Medicine
  • James S. Trimmer University of California Davis
  • Xiaoliang Wang Peking Union Medical College

DOI:

https://doi.org/10.2218/gtopdb/F81/2019.4

Abstract

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

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Published

16-Sep-2019

Issue

Vol. 2019 No. 4 (2019)

Section

Summaries

How to Cite

“Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database” (2019) IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/F81/2019.4.