QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Didier Bagnol Arena Pharmaceuticals
  • Tom I. Bonner National Institute of Mental Health
  • Myrna Carlebur University of Cambridge
  • Anthony P. Davenport University of Cambridge https://orcid.org/0000-0002-2096-3117
  • Stephen M. Foord GlaxoSmithKline
  • Shoji Fukusumi University of Tsukuba
  • Riccarda Granata University of Torino Medical School
  • Dan Larhammar Uppsala University
  • Jérôme Leprince Normandy University https://orcid.org/0000-0002-7814-9927
  • Janet J. Maguire University of Cambridge https://orcid.org/0000-0002-9254-7040
  • Stefany D. Primeaux Louisiana State University
  • Hubert Vaudry Normandy University

DOI:

https://doi.org/10.2218/gtopdb/F54/2019.4

Abstract

The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [16]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by Lee et al. from a hypothalamus cDNA library [15]. However, the reported cDNA (AF411117) is a chimera with bases 1-127 derived from chromosome 1 and bases 155-1368 derived from chromosome 4. When corrected, QRFPR (also referred to as SP9155 or AQ27) encodes a 431 amino acid protein that shares sequence similarities in the transmembrane spanning regions with other peptide receptors. These include neuropeptide FF2 (38%), neuropeptide Y2 (37%) and galanin Gal1 (35%) receptors.

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Published

16-Sep-2019

Issue

Vol. 2019 No. 4 (2019)

Section

Summaries

How to Cite

“QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database” (2019) IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/F54/2019.4.