Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Alessandro Bisello University of Pittsburgh
  • Michael Chorev Harvard Medical School
  • Peter A. Friedman University of Pittsburgh
  • Tom Gardella Massachusetts General Hospital
  • Rebecca Hills University of Edinburgh
  • Harald Jueppner Massachusetts General Hospital
  • T. John Martin University of Melbourne
  • Robert A. Nissenson University of California San Francisco
  • John Thomas Potts, Jr. Massachusetts General Hospital
  • Caroline Silve INSERM
  • Ted B. Usdin National Institute of Mental Health
  • Jean-Pierre Vilardaga University of Pittsburgh

DOI:

https://doi.org/10.2218/gtopdb/F53/2019.4

Abstract

The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors.

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Published

16-Sep-2019

Issue

Vol. 2019 No. 4 (2019)

Section

Summaries

How to Cite

“Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database” (2019) IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/F53/2019.4.