Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Sabine Costagliola Université Libre de Bruxelles
  • James A. Dias New York State Department of Health
  • Marvin Gershengorn National Institutes of Health
  • Deborah L. Segaloff University of Iowa
  • Axel P.N. Themmen Erasmus University Medical Cente
  • Gilbert Vassart Université Libre de Bruxelles

DOI:

https://doi.org/10.2218/gtopdb/F30/2019.4

Abstract

Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].

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Published

16-Sep-2019

Issue

Vol. 2019 No. 4 (2019)

Section

Summaries

How to Cite

“Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database” (2019) IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/F30/2019.4.