Glucagon receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Authors

  • Dominique Bataille INSERM
  • Susan L. Chan University of Nottingham
  • Philippe Delagrange Servier
  • Daniel J. Drucker University of Toronto
  • Burkhard Göke University of Hamburg
  • Rebecca Hills University of Edinburgh
  • Kelly E. Mayo Northwestern University
  • Laurence J. Miller Mayo Clinic https://orcid.org/0000-0002-4554-3872
  • Roberto Salvatori Johns Hopkins Hospital
  • Bernard Thorens University of Lausanne

DOI:

https://doi.org/10.2218/gtopdb/F29/2019.4

Abstract

The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [159]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [116]. For a recent review on review the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the signaling events associated with it, see de Graaf et al., 2016 [87].

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Published

16-Sep-2019

Issue

Vol. 2019 No. 4 (2019)

Section

Summaries

How to Cite

“Glucagon receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database” (2019) IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/F29/2019.4.