Type IX RTKs: MuSK in GtoPdb v.2025.3

Abstract

The muscle-specific kinase MuSK is associated with the formation and organisation of the neuromuscular junction from the skeletal muscle side. agrin forms a complex with low-density lipoprotein receptor-related protein 4 to activate MuSK [5]. MuSK-mediated phosphorylation of downstream targets is involved in stabilised neuromuscular function. It is the target of pathogenic autoantibodies in myasthenia gravis, an autoimmune neuromuscular disease.