Type VI RTKs: PTK7/CCK4 in GtoPdb v.2025.3

Abstract

The PTK7 receptor is associated with polarization of epithelial cells and the development of neural structures. Sequence analysis suggests that the gene product is catalytically inactive as a protein kinase, hence acting as a pseudokinase. There is, however, evidence for a role in Wnt signalling [2], as well as an ability to form heteromers with other RTKs, such as VEGFR2 and ROR2.