Type XVIII RTKs: LMR family in GtoPdb v.2025.3

Abstract

The lemur tail kinase (LMR) family are are unusual amongst the RTKs in possessing a short extracellular domain and extended intracellular domain (hence the 'Lemur' name reflecting the long tail). LMR1 was identified as a potential marker of apoptosis [2], giving rise to the name AATYK (Apoptosis-Associated Tyrosine Kinase); while over-expression induces differentiation in neuroblastoma cells [3]. The LMTK/LMR family have since been identified to have serine/threonine kinase activity, as opposed to tyrosine kinase [4].