Tumour necrosis factor (TNF) receptor family in GtoPdb v.2025.3

Abstract

The TNF receptor family has at least 29 genes, with diverse roles in cell death, inflammation and development. Dysregulated TNFR signalling is associated with many inflammatory disorders, including some forms of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases and for cancer immunotherapy [5, 6, 53].