Receptor tyrosine phosphatase (RTP) family in GtoPdb v.2025.3

Abstract

Receptor tyrosine phosphatases (RTP)- also referred to as receptor-type tyrosine-protein phosphatases (PTPR) - are cell-surface proteins with a single TM region and intracellular phosphatase activity at phosphorylated tyrosine residues. There are 20 family members of classic RPTPs. Many family members exhibit constitutive activity upon heterologous expression, dephosphorylating intracellular targets such as Src tyrosine kinase (SRC) to activate signalling cascades. Family members bind components of the extracellular matrix or cell-surface proteins indicating a role in intercellular communication.