Type VIII RTKs: ROR family in GtoPdb v.2025.3

Abstract

ROR1 and ROR2 are involved in regulating Wnt-5a signalling. There is evidence that ROR1 and ROR2 can form heteromeric complexes. Due to their role in cancer, therapies targeting RORs are under investigation. Thus, ROR1 and ROR2 appear to be activated by Wnt-5a binding to a Frizzled receptor thereby forming a cell-surface multiprotein complex [3].