Type XVI RTKs: DDR (collagen receptor) family in GtoPdb v.2025.3

Abstract

The discoidin domain receptors DDR1 and DDR2 are structurally related receptor tyrosine kinases that function as collagen receptors. The 28 different collagens form the most abundant protein family in man. Collagens are found in the extracellular matrix and are generally deposited there in the form of supramolecular assemblies arranged from triple-helical rope-like structural units. In man, the main collagens include COL1A1, COL2A1, COL3A1 and COL4A1.