Type XII RTKs: TIE family of angiopoietin receptors in GtoPdb v.2025.3

Abstract

The TIE family were initially associated with formation of blood vessels (angiogenesis). Endogenous ligands are angiopoietin-1, angiopoietin-2, and angiopoietin-4. angiopoietin-2 appears to act as an endogenous antagonist of angiopoietin-1 function, thus blocking TIE2-mediated signalling. Due to roles in blood vessel formation, monoclonal antibodies are being developed against the ligand Ang2 (cyamemazine57) or a bispecific antibody against VEGF and Ang2 (faricimab) for the treatment of ocular diseases.