Type X RTKs: HGF (hepatocyte growth factor) receptor family in GtoPdb v.2025.3

Abstract

The hepatocyte growth factor (HGF) receptor family - MET and Ron - regulate maturation of the liver in the embryo, as well as having roles in the adult, for example, in the innate immune system. HGF is synthesized as a single gene product, which is post-translationally processed to yield a heterodimer linked by a disulphide bridge. The maturation of HGF is enhanced by a serine protease, HGF activating complex, and inhibited by HGF-inhibitor 1, a serine protease inhibitor. MST1, the ligand of Ron, is two disulphide-linked peptide chains generated by proteolysis of a single gene product.