Type II receptor serine/threonine kinases in GtoPdb v.2025.3

Abstract

Type II protein receptor serine/threonine kinases interact with transforming growth factor beta (TGFβ), bone morphogenic protein (BMP) or MÀllerian inhibiting substrate (MIS). Type II RSTKs then phosphorylate the kinase domain of their Type I RSTK partner - sometimes referred to as the signal propagating unit. This causes displacement of protein partners, such as the FKBP12 FK506-binding protein FKBP1A (P62942) and allowing the binding and phosphorylation of particular members of the Smad family.