SLC6 neurotransmitter transporter family in GtoPdb v.2025.3

Abstract

Members of the solute carrier family 6 (SLC6) of sodium- and (sometimes chloride-) dependent neurotransmitter transporters [32, 2, 23, 76] are primarily plasma membrane located and may be divided into four subfamilies that transport monoamines, GABA, glycine and neutral amino acids, plus the related bacterial NSS transporters [110]. The members of this superfamily share a structural motif of 10 TM segments that has been observed in crystal structures of the NSS bacterial homolog LeuT_Aa, a Na⁺-dependent amino acid transporter from Aquiflex aeolicus [139] and in several other transporter families structurally related to LeuT [49].