Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2025.3

Abstract

Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated K_V subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca²⁺-activated Slo subfamily (actually with 6 or 7TM) and the Ca²⁺- and Na⁺-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [144]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. K_V1.1 with K_V1.2; KCNQ2 with KCNQ3).