Somatostatin receptors in GtoPdb v.2025.3

Authors

  • Corinne Bosquet University Toulouse III Paul Sabatier https://orcid.org/0000-0002-2501-0593
  • Wolfgang Meyerhof Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
  • Anne-Marie O'Carroll University of Bristol https://orcid.org/0000-0001-5255-8506
  • Yogesh C. Patel McGill University
  • Terry Reisine ActiveSite Biotech
  • Jean-Claude Reubi University of Berne
  • Marcus Schindler Boehringer Ingelheim Pharma
  • Herbert Schmid Novartis Institutes for Biomedical Research
  • Agnes Schonbrunn University of Texas
  • Stefan Schulz Friedrich Schiller University
  • John E. Taylor Biomeasure Inc
  • Giovanni Tulipano University of Brescia
  • Annamaria Vezzani Istituto di Ricerche Farmacologiche Mario Negri
  • Shlomo Melmed Cedars-Sinai Medical Center
  • Amelie Lupp Friedrich-Schiller-University
  • Justo P. Castaño University of Cordoba
  • Zsolt Csaba Université Paris Diderot
  • Micheal Culler Ipsen
  • Pascal Dournaud Université Paris Diderot
  • Jacques Epelbaum INSERM- UNIVERSITE PARIS DESCARTES UMR. 549
  • Wasyl Feniuk University of Cambridge
  • Anthony Harmar University of Edinburgh
  • Rebecca Hills University of Edinburgh
  • Leo Hofland Erasmus Medical Center
  • Daniel Hoyer University of Melbourne https://orcid.org/0000-0002-1405-7089
  • Patrick P. A. Humphrey University of Cambridge
  • Hans-Jürgen Kreienkamp University Medical Center Hamburg-Eppendorf
  • Hans-Jürgen Wester Technische Universität München

DOI:

https://doi.org/10.2218/gtopdb/F61/2025.3

Abstract

Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [101]). Activation of these receptors produces a wide range of physiological effects throughout the body including the inhibition of secretion of many hormones. Endogenous ligands for these receptors are somatostatin-14 (SRIF-14) and somatostatin-28 (SRIF-28). cortistatin-14 has also been suggested to be an endogenous ligand for somatostatin receptors [62].

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Published

10-Sep-2025

Issue

Vol. 2025 No. 3 (2025)

Section

Articles

License

Copyright (c) 2025 The authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

How to Cite

“Somatostatin receptors in GtoPdb v.2025.3” (2025) IUPHAR/BPS Guide to Pharmacology CITE, 2025(3). doi:10.2218/gtopdb/F61/2025.3.