Neuropeptide S receptor in GtoPdb v.2025.3

Abstract

The neuropeptide S receptor (NPS receptor) responds to the 20 amino-acid peptide neuropeptide S derived from a precursor (NPS, P0C0P6). NPS activates its receptor at low nanomolar concentrations elevating intracellular cAMP and calcium levels [74]. Currently, some peptidic and small molecule NPS receptor antagonists are available as research tools [30, 82, 9, 62]. No NPS receptor ligands are currently used clinically.