Adhesion Class GPCRs in GtoPdb v.2025.3

Abstract

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [15] containing a GPCR proteolysis site (GPS). The N-terminal extracellular region often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [120, 468]. Several receptors have been suggested to function as mechanosensors [355, 322, 442, 49, 327]. Cryo-EM structures of the 7-transmembrane domain of several adhesion GPCRs have been determined recently [326, 31, 450, 241, 334, 336, 490, 327]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [145].