Complement peptide receptors in GtoPdb v.2025.3

Antonia Cianciulli; Arun K. Shukla; Maria A. Panaro; Peter Monk; Vincenzo Mitolo; Xaria X. Li; John D. Lee; Owen Hawksworth; Liam Coulthard; Trent M. Woodruff

doi:10.2218/gtopdb/F5/2025.3

Authors

Antonia Cianciulli University of Bari https://orcid.org/0000-0002-9851-3124
Arun K. Shukla Indian Institute of Technology https://orcid.org/0000-0003-2910-8288
Maria A. Panaro University of Bari
Peter Monk Sheffield University Medical School https://orcid.org/0000-0003-4637-3059
Vincenzo Mitolo Formerly of University of Bari
Xaria X. Li The University of Queensland https://orcid.org/0000-0001-5924-2977
John D. Lee University of Queensland https://orcid.org/0000-0002-9976-7396
Owen Hawksworth University of Queensland
Liam Coulthard University of Queensland
Trent M. Woodruff University of Queensland https://orcid.org/0000-0003-1382-911X

DOI:

https://doi.org/10.2218/gtopdb/F5/2025.3

Abstract

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [116]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3a receptor, C5a receptor 1 and C5a receptor 2), causing cell recruitment and triggering cellular degranulation that contributes to local inflammation.

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Complement peptide receptors in GtoPdb v.2025.3

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