Formylpeptide receptors in GtoPdb v.2025.1

Magnus Bäck; Richard D. Ye; Ji Ming Wang; Takao Shimizu; Charles N. Serhan; G. Enrico Rovati; Mark Quinn; Marc Parmentier; Philip M. Murphy; Craig Gerard; Jilly F. Evans; Jeffrey Drazen; Claes Dahlgren; Sven-Erik Dahlén; Nan Chiang; François Boulay; Takehiko Yokomizo

doi:10.2218/gtopdb/F23/2025.1

Authors

Magnus Bäck Karolinska Institutet https://orcid.org/0000-0003-0853-5141
Richard D. Ye The Chinese University of Hong Kong, Shenzhen
Ji Ming Wang Frederick National Laboratory for Cancer Research
Takao Shimizu University of Tokyo
Charles N. Serhan Harvard University https://orcid.org/0000-0003-4627-8545
G. Enrico Rovati University of Milan https://orcid.org/0000-0002-8788-9783
Mark Quinn Montana State University
Marc Parmentier Université Libre de Bruxelles
Philip M. Murphy National Institutes of Health
Craig Gerard Harvard Medical School and Children's Hospital
Jilly F. Evans PharmAkea
Jeffrey Drazen Harvard University
Claes Dahlgren University of Göteborg
Sven-Erik Dahlén Karolinska Institutet https://orcid.org/0000-0002-4993-4002
Nan Chiang Brigham and Women's Hospital https://orcid.org/0000-0003-1963-1585
François Boulay Commissariat à l’Energie Atomique
Takehiko Yokomizo Juntendo University

DOI:

https://doi.org/10.2218/gtopdb/F23/2025.1

Abstract

The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [150]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLF) and endogenous ligands such as lipoxin A₄ (LXA₄), 15-epi-lipoxin A₄, annexin I , cathepsin G, amyloid β42, serum amyloid A and spinorphin, derived from β-haemoglobin. FPR1 also serves as a plague receptor for selective destruction of human immune cells by Y. pestis [135]. The FPR1/2 agonists 'compound 17b' and 'compound 43' have shown cardiac protective functions [149, 64].

Formylpeptide receptors in GtoPdb v.2025.1

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