IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F218/2023.1

SLC31 family of copper transporters in GtoPdb v.2023.1



Svetlana Lutsenko1
  1. Johns Hopkins Medical Institute, USA


Abstract

SLC31 family members, alongside the Cu-ATPases are involved in the regulation of cellular copper levels. The CTR1 transporter is a cell-surface transporter to allow monovalent copper accumulation into cells, while CTR2 appears to be a vacuolar/vesicular transporter [5]. Functional copper transporters appear to be trimeric with each subunit having three TM regions and an extracellular N-terminus. CTR1 is considered to be a higher affinity copper transporter compared to CTR2. The stoichiometry of copper accumulation is unclear, but appears to be energy-independent [4].

Contents

This is a citation summary for SLC31 family of copper transporters in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [2].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

SLC31 family of copper transporters
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=218
    Transporters
            CTR1(Copper transporter 1)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1131
            CTR2(Copper transporter 2)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1132

References

  1. Blair BG, Larson CA, Safaei R and Howell SB. (2009) Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. Clin Cancer Res 15: 4312-21 [PMID:19509135]
  2. Buneman P, Christie G, Davies JA, Dimitrellou R, Harding SD, Pawson AJ, Sharman JL and Wu Y. (2020) Why data citation isn't working, and what to do about it Database 2020 [PMID:32367113]
  3. Ishida S, Lee J, Thiele DJ and Herskowitz I. (2002) Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci USA 99: 14298-302 [PMID:12370430]
  4. Lee J, Peña MM, Nose Y and Thiele DJ. (2002) Biochemical characterization of the human copper transporter Ctr1. J Biol Chem 277: 4380-7 [PMID:11734551]
  5. Rees EM, Lee J and Thiele DJ. (2004) Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. J Biol Chem 279: 54221-9 [PMID:15494390]