IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F153/2023.1
ABCC subfamily in GtoPdb v.2023.1
Mary Vore1
- University of Kentucky, USA
Abstract
Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs). The MRP proteins are found throughout nature and they mediate many important functions. They are known to be involved in ion transport, toxin secretion, and signal transduction [7, 2].
Contents
This is a citation summary for ABCC subfamily in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts. For further details see [5].
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
ABCC subfamily
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=153
Transporters
MRP1(ABCC1)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=779
MRP2, cMOAT(ABCC2)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=780
MRP3(ABCC3)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=781
MRP4(ABCC4)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=782
MRP5(ABCC5)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=783
MRP6(ABCC6)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=784
SUR1(ATP-binding cassette, sub-family C (CFTR/MRP), member 8)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2594
SUR2(ABCC9)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2746
MRP7(ABCC10)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=785
MRP8(ABCC11)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=786
MRP9(ABCC12)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=787
References
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- Sager G, Ørvoll EØ, Lysaa RA, Kufareva I, Abagyan R and Ravna AW. (2012) Novel cGMP efflux inhibitors identified by virtual ligand screening (VLS) and confirmed by experimental studies. J Med Chem 55: 3049-57 [PMID:22380603]
- Silbermann K, Stefan SM, Elshawadfy R, Namasivayam V and Wiese M. (2019) Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. J Med Chem 62: 4383-4400 [PMID:30925062]
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- Zelcer N, Reid G, Wielinga P, Kuil A, van der Heijden I, Schuetz JD and Borst P. (2003) Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J 371: 361-7 [PMID:12523936]
- Zhang X, Qiu Y, Li X, Bhattacharjee S, Woods M, Kraft P, Lundeen SG and Sui Z. (2009) Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence. Bioorg Med Chem 17: 855-66 [PMID:19101153]