IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F84/2023.1

1A. Thyroid hormone receptors in GtoPdb v.2023.1



Douglas Forrest1, Anthony N. Hollenberg2 and Paul Webb3
  1. National Institutes of Health, USA
  2. Harvard Medical School, USA
  3. The Houston Methodist Hospital Research Institute, USA


Abstract

Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [12, 2]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and cardiovascular homeostasis. TRs are activated by thyroxine (T4) and thyroid hormone (triiodothyronine). Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. NH-3 has been described as an antagonist at TRs with modest selectivity for TRβ [42].

Contents

This is a citation summary for 1A. Thyroid hormone receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [5].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

1A. Thyroid hormone receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=84
Introduction to 1A. Thyroid hormone receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=84
    Receptors
            Thyroid hormone receptor-α
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=588
            Thyroid hormone receptor-β
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=589

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