1. University of Edinburgh, UK
2. The University of Edinburgh, UK
3. Université de Montpellier, France
4. University of California Irvine, USA

Abstract

Prokineticin receptors, PKR₁ and PKR₂ (provisional nomenclature as recommended by NC-IUPHAR [26]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [71]) is a potent, non-selective agonist at prokineticin receptors [46], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [49]), is equipotent at recombinant PKR₁ and PKR₂ [53], and has high potency in macrophage chemotaxis assays, which are lost in PKR₁-null mice.

Contents

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