IUPHAR/BPS Guide to Pharmacology CITE

Coronavirus (CoV) proteins in GtoPdb v.2022.3

Stephen P.H. Alexander1, Jonathan K. Ball1 and Theocharis Tsoleridis1
  1. University of Nottingham, UK


Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 years as serious human pathogens: SARS-CoV was identified as the causative agent in an outbreak in 2002-2003, Middle East respiratory syndrome (MERS) CoV emerged in 2012 and the novel coronavirus SARS-CoV-2 emerged in 2019-2020. SARS-CoV-2 is the virus responsible for the infectious disease termed COVID-19 (WHO Technical Guidance 2020).


This is a citation summary for Coronavirus (CoV) proteins in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [15].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Coronavirus (CoV) proteins
Introduction to Coronavirus (CoV) proteins
            CoV Envelope protein
            CoV 3C-like (main) protease
            CoV Membrane glycoprotein
            CoV Non-structural protein 6
            CoV Non-structural protein 7b
            CoV Non-structural protein 8
            CoV Non-structural protein 14
            CoV Non-structural protein 15
            CoV Nucleoprotein
            CoV Papain-like protease
            CoV Protein 3a
            CoV Protein 7a
            CoV Protein 9b
            CoV Replicase polyprotein 1a
            CoV Replicase polyprotein 1ab
            CoV RNA-dependent RNA polymerase
            CoV Spike glycoprotein


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