Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [121]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.
Table 1: Class A orphan GPCRs with putative endogenous ligands
GPR3 | GPR4 | GPR6 | GPR12 | GPR15 | GPR17 | GPR20 |
GPR22 | GPR26 | GPR31 | GPR34 | GPR35 | GPR37 | GPR39 |
GPR50 | GPR63 | GPR65 | GPR68 | GPR75 | GPR84 | GPR87 |
GPR88 | GPR132 | GPR149 | GPR161 | GPR183 | LGR4 | LGR5 |
LGR6 | MAS1 | MRGPRD | MRGPRX1 | MRGPRX2 | P2RY10 | TAAR2 |