IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F16/2022.3

Class A Orphans in GtoPdb v.2022.3



Stephen P.H. Alexander1, Jim Battey2, Helen E. Benson3, Richard V. Benya4, Tom I. Bonner5, Anthony P. Davenport6, Khuraijam Dhanachandra Singh7, Satoru Eguchi8, Anthony Harmar3, Nick Holliday1, Robert T. Jensen2, Sadashiva Karnik7, Evi Kostenis9, Wen Chiy Liew3, Amy E. Monaghan3, Chido Mpamhanga10, Richard Neubig11, Adam J Pawson12, Jean-Philippe Pin13, Joanna L. Sharman3, Michael Spedding14, Eliot Spindel15, Leigh Stoddart16, Laura Storjohann17, Walter G. Thomas18, Kalyan Tirupula7 and Patrick Vanderheyden19
  1. University of Nottingham, UK
  2. National Institutes of Health, USA
  3. University of Edinburgh, UK
  4. University of Illinois at Chicago, USA
  5. National Institute of Mental Health, USA
  6. University of Cambridge, UK
  7. Cleveland Clinic Lerner Research Institute, USA
  8. Temple University, USA
  9. University of Bonn, Germany
  10. LifeArc, UK
  11. Michigan State University, USA
  12. The University of Edinburgh, UK
  13. Université de Montpellier, France
  14. Spedding Research Solutions SARL, France
  15. Oregon Health & Science University, USA
  16. University of Glasgow, UK
  17. University of Utah, USA
  18. University of Queensland, Australia
  19. Vrije Universiteit Brussel, Belgium


Abstract

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [121]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.

Table 1: Class A orphan GPCRs with putative endogenous ligands

GPR3GPR4GPR6GPR12GPR15GPR17GPR20
GPR22GPR26GPR31GPR34GPR35GPR37GPR39
GPR50GPR63GPR65GPR68GPR75GPR84GPR87
GPR88GPR132GPR149GPR161GPR183LGR4LGR5
LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2

In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).

Contents

This is a citation summary for Class A Orphans in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [68].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Class A Orphans
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=16
Introduction to Class A Orphans
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=16
    Receptors
            GPR3
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=83
            GPR4
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=84
            GPR6
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=85
            GPR42
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=228
            GPR12
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=86
            GPR15
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=87
            GPR17
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=88
            GPR19
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=90
            GPR20
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=91
            GPR21
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=92
            GPR22
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=93
            GPR25
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=95
            GPR26
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=96
            GPR27
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=97
            GPR31
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=98
            GPR32
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=99
            GPR33
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=100
            GPR34
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=101
            GPR35
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=102
            GPR37
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=103
            GPR37L1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=104
            GPR39
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=105
            GPR45
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=106
            GPR50
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=107
            GPR52
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=108
            GPR61
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=110
            GPR62
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=111
            GPR63
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=112
            GPR65
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=113
            GPR68
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=114
            GPR75
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=115
            GPR78
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=116
            GPR79
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=117
            GPR82
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=118
            GPR83
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=119
            GPR84
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=120
            GPR85
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=121
            GPR87
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=122
            GPR88
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=123
            GPR101
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=125
            GPR132
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=128
            GPR135
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=129
            GPR139
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=130
            GPR141
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=131
            GPR142
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=132
            GPR146
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=133
            GPR148
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=134
            GPR149
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=135
            GPR150
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=136
            GPR151
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=137
            GPR152
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=138
            GPR153
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=139
            GPR160
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=140
            GPR161
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=141
            GPR162
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=142
            GPR171
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=143
            GPR173
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=144
            GPR174
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=145
            GPR176
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=637
            GPR182
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=146
            GPR183
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=81
            LGR4
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=147
            LGR5
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=148
            LGR6
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=149
            MAS1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=150
            MAS1L
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=151
            MRGPRD
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=152
            MRGPRE
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=153
            MRGPRF
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=154
            MRGPRG
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=155
            MRGPRX1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=156
            MRGPRX2
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=157
            MRGPRX3
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=158
            MRGPRX4
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=159
            P2RY8
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=164
            P2RY10
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=165
            TAAR2
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=167
            TAAR3
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=168
            TAAR4P
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=169
            TAAR5
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=170
            TAAR6
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=171
            TAAR8
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=172
            TAAR9
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=173

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