IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F52/2021.3

P2Y receptors in GtoPdb v.2021.3



Maria-Pia Abbracchio1, Jean-Marie Boeynaems2, José L. Boyer3, Geoffrey Burnstock4, Stefania Ceruti1, Marta Fumagalli1, Christian Gachet5, Rebecca Hills6, Robert G. Humphries7, Kazu Inoue8, Kenneth A. Jacobson9, Charles Kennedy10, Brian F. King11, Davide Lecca1, Christa E. Müller12, Maria Teresa Miras-Portugal13, Vera Ralevic14 and Gary A. Weisman15
  1. University of Milan, Italy
  2. Université Libre de Bruxelles, Belgium
  3. University of North Carolina, USA
  4. Autonomic Neuroscience Centre, University College London, UK
  5. INSERM, France
  6. University of Edinburgh, UK
  7. AstraZeneca, UK
  8. University of Kyushu, Japan
  9. National Institutes of Health, USA
  10. University of Strathclyde, UK
  11. University College London, UK
  12. Universität Bonn, Germany
  13. Universidad Complutense de Madrid, Spain
  14. University of Nottingham, UK
  15. University of Missouri, USA


Abstract

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5, 192]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [47, 110, 190, 383, 396]. Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [241], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [53, 323].

Contents

This is a citation summary for P2Y receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [44].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

P2Y receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=52
Introduction to P2Y receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=52
    Receptors
            P2Y1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=323
            P2Y2 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=324
            P2Y4 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=325
            P2Y6 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=326
            P2Y11 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=327
            P2Y12 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=328
            P2Y13 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=329
            P2Y14 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=330

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