IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F17/2021.3

Adhesion Class GPCRs in GtoPdb v.2021.3

Demet Arac-Ozkan¹, Gabriela Aust², Tom I. Bonner³, Heike Cappallo-Obermann⁴, Caroline Formstone⁵, Jörg Hamann⁶, Breanne Harty⁷, Henrike Heyne², Christiane Kirchhoff⁴, Barbara Knapp⁸, Arunkumar Krishnan⁹, Tobias Langenhan², Diana Le Duc², Hsi-Hsien Lin¹⁰, David C. Martinelli¹¹, Kelly Monk⁷, Xianhua Piao¹², Simone Prömel², Torsten Schöneberg², Helgi Schiöth¹³, Kathleen Singer¹², Martin Stacey¹⁴, Yuri Ushkaryov¹⁵, Uwe Wolfrum⁸ and Lei Xu¹⁶

University of Chicago, USA
University of Leipzig, Germany
National Institute of Mental Health, USA
University of Hamburg, Germany
King's College London, UK
University of Amsterdam, The Netherlands
Washington University, USA
Johannes-Gutenberg Universitaet Mainz, Germany
Uppsala Universitet, Sweden
Chang Gung University, Taiwan
Stanford University, USA
Boston Children's Hospital, USA
Uppsala University, Sweden
University of Leeds, UK
University of Kent, UK
University of Rochester, USA

Abstract

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [9] containing a GPCR proteolytic site. The N-terminus often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [101, 403]. Several receptors have been suggested to function as mechanosensors [309, 280, 383, 35]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [122].

This is a citation summary for Adhesion Class GPCRs in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [39].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

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Adhesion Class GPCRs in GtoPdb v.2021.3

Abstract

Contents

Database links

References