IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F891/2021.2

Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2



Katelin E. Ahlers-Dannen1, Mohammed Alqinyah2, Christopher Bodle1, Josephine Bou Dagher2, Bandana Chakravarti1, Shreoshi P. Choudhuri3, Kirk M. Druey4, Rory A. Fisher1, Kyle J. Gerber5, John R. Hepler5, Shelley B. Hooks2, Havish S. Kantheti3, Behirda Karaj6, Somayeh Layeghi-Ghalehsoukhteh7, Jae-Kyung Lee2, Zili Luo1, Kirill Martemyanov8, Luke D. Mascarenhas3, Harrison J. McNabb9, Carolina Montañez-Miranda10, Osita W. Ogujiofor3, Hoa Phan Thi Nhu6, David L. Roman1, Vincent Shaw6, Benita Sjögren9, Mackenzie M. Spicer1, Katherine E. Squires5, Laurie Sutton8, Menbere Wendimu2, Thomas M. Wilkie3, Keqiang Xie8, Qian Zhang9 and Yalda Zolghadri7
  1. University of Iowa, USA
  2. University of Georgia, USA
  3. University of Texas Southwestern Medical Center, USA
  4. National Institutes of Health, USA
  5. Emory University, USA
  6. Michigan State University, USA
  7. Shiraz University, Iran
  8. Scripps Research Institute, USA
  9. Purdue University, USA
  10. Emory University School of Medicine, USA


Abstract

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins stabilize the transition state for GTP hydrolysis on Gα and thus induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs. This GTPase accelerating protein (GAP) activity is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains. RGS proteins are divided into four families, R4, R7, R12 and RZ based on sequence homology, domain structure as well as specificity towards Gα subunits. For reviews on RGS proteins and their potential as therapeutic targets, see e.g. [225, 529, 578, 583, 584, 742, 753, 444, 10].

Contents

This is a citation summary for Regulators of G protein Signaling (RGS) proteins in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [65].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Regulators of G protein Signaling (RGS) proteins
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=891
    RZ family
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=892
        Targets
                RGS17(regulator of G-protein signaling 17)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2801
                RGS19(regulator of G-protein signaling 19)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2802
                RGS20(regulator of G-protein signaling 20)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2803
    R4 family
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=893
        Targets
                RGS1(regulator of G-protein signaling 1)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2804
                RGS2(regulator of G-protein signaling 2)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2808
                RGS3(regulator of G-protein signaling 3)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2810
                RGS4(regulator of G-protein signaling 4)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2811
                RGS5(regulator of G-protein signaling 5)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2812
                RGS8(regulator of G-protein signaling 8)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2813
                RGS13(regulator of G-protein signaling 13)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2805
                RGS16(regulator of G-protein signaling 16)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2806
                RGS18(regulator of G-protein signaling 18)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2807
                RGS21(regulator of G-protein signaling 21)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2809
    R7 family
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=894
        Targets
                RGS6(regulator of G-protein signaling 6)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2815
                RGS7(regulator of G-protein signaling 7)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2816
                RGS9(regulator of G-protein signaling 9)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2817
                RGS11(regulator of G-protein signaling 11)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2814
    R12 family
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=895
        Targets
                RGS10(regulator of G-protein signaling 10)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2818
                RGS12(regulator of G-protein signaling 12)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2819
                RGS14(regulator of G-protein signaling 14)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2820

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