1. Karolinska Institutet, Sweden
2. Commissariat à l’Energie Atomique, France
3. Brigham and Women's Hospital, USA
4. University of Göteborg, Sweden
5. Harvard University, USA
6. PharmAkea, USA
7. Harvard Medical School and Children's Hospital, USA
8. National Institutes of Health, USA
9. Université Libre de Bruxelles, Belgium
10. Montana State University, USA
11. University of Milan, Italy
12. University of Tokyo, Japan
13. Frederick National Laboratory for Cancer Research, USA
14. The Chinese University of Hong Kong, Shenzhen, China
15. Juntendo University, Japan

Abstract

The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [196]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLP) and endogenous ligands such as lipoxin A₄ (LXA₄), 15-epi-lipoxin A₄, annexin I , cathepsin G, amyloid β42, serum amyloid A and spinorphin, derived from β-haemoglobin. FPR1 also serves as a plague receptor for selective destruction of human immune cells by Y. pestis [135]. The FPR1/2 agonists 'compound 17b' and 'compound 43' have shown cardiac protective functions [149, 64].

Contents

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [18].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

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