IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F5/2020.5

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database



Antonia Cianciulli1, Liam Coulthard2, Owen Hawksworth2, John D. Lee2, Xiang X. Li3, Vincenzo Mitolo1, Peter Monk4, Maria A. Panaro1 and Trent M. Woodruff2
  1. University of Bari, Italy
  2. University of Queensland, Australia
  3. The University of Queensland, Australia
  4. Sheffield University Medical School, UK


Abstract

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.

Contents

This is a citation summary for Complement peptide receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Complement peptide receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=5
Introduction to Complement peptide receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=5
    Receptors
            C3a receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=31
            C5a1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=32
            C5a2 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=33

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