IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F799/2019.4
Hydrolases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Stephen P.H. Alexander1,
Patrick Doherty2,
David Fairlie3,
Christopher J. Fowler4,
Christopher M. Overall5,
Neil Rawlings6,
Christopher Southan7 and
Anthony J. Turner8
- University of Nottingham, UK
- King's College London, UK
- University of Queensland, Australia
- University Hospital of Umeå, Sweden
- University of British Columbia, Canada
- Wellcome Trust Sanger Institute, UK
- University of Edinburgh, Sweden
- University of Leeds, UK
Abstract
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins.
Contents
This is a citation summary for Hydrolases in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts.
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
Hydrolases
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=799
Enzymes
AChE(acetylcholinesterase (Cartwright blood group))
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465
BChE(butyrylcholinesterase)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2471
DAGLα(Diacylglycerol lipase α)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1396
DAGLβ(Diacylglycerol lipase β)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1397
CES1(carboxylesterase 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2592
NTPDase-1(ectonucleoside triphosphate diphosphohydrolase 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2888
NTPDase-2(ectonucleoside triphosphate diphosphohydrolase 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2889
epoxide hydrolase 2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2970
FAAH(Fatty acid amide hydrolase)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1400
Leukotriene A4 hydrolase
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1395
LIPE(lipase E, hormone sensitive type)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2593
LIPG(lipase G, endothelial type)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2591
MAGL(Monoacylglycerol lipase)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1399
nudix hydrolase 7
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3085
PNLIP(pancreatic lipase)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2590
PLA2-G7
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1432
sPLA2-2A
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1417
PLD2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1434
vanin 1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3063
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