IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F242/2019.4
Cytochrome P450 (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Kathryn Burns1 and
Nuala Ann Helsby1
- University of Auckland, New Zealand
Abstract
The cytochrome P450 enzyme family (CYP450), E.C. 1.14.-.-, were originally defined by their strong absorbance at 450 nm due to the reduced carbon monoxide-complexed haem component of the cytochromes. They are an extensive family of haem-containing monooxygenases with a huge range of both endogenous and exogenous substrates. These include sterols, fat-soluble vitamins, pesticides and carcinogens as well as drugs. The substrates of some orphan CYP are not known. Listed below are the human enzymes; their relationship with rodent CYP450 enzyme activities is obscure in that the species orthologue may not catalyse the metabolism of the same substrates. Although the majority of CYP450 enzyme activities are concentrated in the liver, the extrahepatic enzyme activities also contribute to patho/physiological processes. Genetic variation of CYP450 isoforms is widespread and likely underlies a significant proportion of the individual variation to drug administration.
Contents
This is a citation summary for Cytochrome P450 in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts.
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
Cytochrome P450
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=242
CYP1 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=261
Enzymes
CYP1A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1318
CYP1A2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1319
CYP1B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1320
CYP2 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=262
Enzymes
CYP2A6
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1321
CYP2A7
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1322
CYP2A13
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1323
CYP2B6
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1324
CYP2C8
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1325
CYP2C9
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1326
CYP2C18
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1327
CYP2C19
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1328
CYP2D6
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1329
CYP2E1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1330
CYP2F1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1331
CYP2J2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1332
CYP2R1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1333
CYP2S1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1334
CYP2U1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1335
CYP2W1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1336
CYP3 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=263
Enzymes
CYP3A4
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1337
CYP3A5
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1338
CYP3A7
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1339
CYP3A43
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1340
CYP4 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=264
Enzymes
CYP4A11
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1341
CYP4A22
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1342
CYP4B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1343
CYP4F2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1344
CYP4F3
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1345
CYP4F8
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1346
CYP4F11
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1347
CYP4F12
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1348
CYP4F22
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1349
CYP4V2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1350
CYP4X1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1351
CYP4Z1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1352
CYP5, CYP7 and CYP8 families
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=265
Enzymes
Thromboxane synthase(CYP5A1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1353
Prostacyclin synthase(CYP8A1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1356
CYP7A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1354
CYP7B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1355
CYP8B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1357
CYP11, CYP17, CYP19, CYP20 and CYP21 families
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=266
Enzymes
CYP11A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1358
CYP11B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1359
Aldosterone synthase(CYP11B2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1360
CYP17A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1361
Aromatase(CYP19A1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1362
CYP20A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1363
CYP21A2
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1364
CYP24, CYP26 and CYP27 families
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=267
Enzymes
CYP24A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1365
CYP26A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1366
CYP26B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1367
CYP26C1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1368
Sterol 27-hydroxylase(CYP27A1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1369
CYP27B1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1370
CYP27C1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1371
CYP39, CYP46 and CYP51 families
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=268
Enzymes
CYP39A1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1372
Cholesterol 24-hydroxylase(CYP46A1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1373
Lanosterol 14-α-demethylase(CYP51A1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1374
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