IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F186/2019.4

SLC14 family of facilitative urea transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Gavin Stewart1
  1. University College Dublin, Ireland


Abstract

As a product of protein catabolism, urea is moved around the body and through the kidneys for excretion. Although there is experimental evidence for concentrative urea transporters, these have not been defined at the molecular level. The SLC14 family are facilitative transporters, allowing urea movement down its concentration gradient. Multiple splice variants of these transporters have been identified; for UT-A transporters, in particular, there is evidence for cell-specific expression of these variants with functional impact [3]. Topographical modelling suggests that the majority of the variants of SLC14 transporters have 10 TM domains, with a glycosylated extracellular loop at TM5/6, and intracellular C- and N-termini. The UT-A1 splice variant, exceptionally, has 20 TM domains, equivalent to a combination of the UT-A2 and UT-A3 splice variants.

Contents

This is a citation summary for SLC14 family of facilitative urea transporters in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

SLC14 family of facilitative urea transporters
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=186
    Transporters
            UT-B(Erythrocyte urea transporter)
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=982
            UT-A(Kidney urea transporter)
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=983

References

  1. Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS and Anderson MO. (2013) 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorg. Med. Chem. Lett. 23: 3338-41 [PMID:23597791]
  2. Maciver B, Smith CP, Hill WG and Zeidel ML. (2008) Functional characterization of mouse urea transporters UT-A2 and UT-A3 expressed in purified Xenopus laevis oocyte plasma membranes. Am. J. Physiol. Renal Physiol. 294: F956-64 [PMID:18256317]
  3. Stewart G. (2011) The emerging physiological roles of the SLC14A family of urea transporters. Br. J. Pharmacol. 164: 1780-92 [PMID:21449978]
  4. Zhao D, Sonawane ND, Levin MH and Yang B. (2007) Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim. Biophys. Acta 1768: 1815-21 [PMID:17506977]