IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F149/2019.4
SLC28 and SLC29 families of nucleoside transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
James R. Hammond1
- University of Alberta, Canada
Abstract
Nucleoside transporters are divided into two families, the sodium-dependent, concentrative solute carrier family 28 (SLC28) and the equilibrative, solute carrier family 29 (SLC29). The endogenous substrates are typically nucleosides, although some family members can also transport nucleobases and organic cations.
Contents
This is a citation summary for SLC28 and SLC29 families of nucleoside transporters in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts.
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
SLC28 and SLC29 families of nucleoside transporters
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=149
SLC28 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=215
Transporters
CNT1(Sodium/nucleoside cotransporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1114
CNT2(Sodium/nucleoside cotransporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1115
CNT3(Solute carrier family 28 member 3)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1116
SLC29 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=216
Transporters
ENT1(Equilibrative nucleoside transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1117
ENT2(Equilibrative nucleoside transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1118
ENT3(Equilibrative nucleoside transporter 3)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1119
PMAT(Plasma membrane monoamine transporter)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1120
References
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- Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE and Young JD. (2005) Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 280: 15880-7 [PMID:15701636]
- Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER, Sun L, Tellez J, Ritzel MW and Claycomb WC et al.. (2006) Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ. Res. 99: 510-9 [PMID:16873718]
- Choi MK. (2012) Variability of gemcitabine accumulation and its relationship to expression of nucleoside transporters in peripheral blood mononuclear cells. Arch. Pharm. Res. 35: 921-7 [PMID:22644860]
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- Engel K and Wang J. (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol. Pharmacol. 68: 1397-407 [PMID:16099839]
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- Hammond JR. (2000) Interaction of a series of draflazine analogues with equilibrative nucleoside transporters: species differences and transporter subtype selectivity. Naunyn Schmiedebergs Arch. Pharmacol. 361: 373-82 [PMID:10763851]
- Hammond JR and Archer RG. (2004) Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazolinedione hydrochloride (KF24345) with the es and ei subtypes of equilibrative nucleoside transporters. J. Pharmacol. Exp. Ther. 308: 1083-93 [PMID:14634039]
- Ho HT, Pan Y, Cui Z, Duan H, Swaan PW and Wang J. (2011) Molecular analysis and structure-activity relationship modeling of the substrate/inhibitor interaction site of plasma membrane monoamine transporter. J. Pharmacol. Exp. Ther. 339: 376-85 [PMID:21816955]
- Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP and Park H et al.. (2012) Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis. Science 335: 89-92 [PMID:22174130]
- Kang N, Jun AH, Bhutia YD, Kannan N, Unadkat JD and Govindarajan R. (2010) Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability. J. Biol. Chem. 285: 28343-52 [PMID:20595384]
- Larráyoz IM, Fernández-Nistal A, Garcés A, Gorraitz E and Lostao MP. (2006) Characterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methods. Am. J. Physiol., Cell Physiol. 291: C1395-404 [PMID:16837649]
- Owen RP, Badagnani I and Giacomini KM. (2006) Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. J. Biol. Chem. 281: 26675-82 [PMID:16840788]
- Sundaram M, Yao SY, Ng AM, Griffiths M, Cass CE, Baldwin SA and Young JD. (1998) Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs. J. Biol. Chem. 273: 21519-25 [PMID:9705281]
- Tatani K, Hiratochi M, Nonaka Y, Isaji M and Shuto S. (2015) Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett 6: 244-8 [PMID:25815140]
- Wang C, Lin W, Playa H, Sun S, Cameron K and Buolamwini JK. (2013) Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem. Pharmacol. 86: 1531-40 [PMID:24021350]
- Wang J. (2016) The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition. Clin. Pharmacol. Ther. 100: 489-499 [PMID:27506881]
- Warraich S, Bone DB, Quinonez D, Ii H, Choi DS, Holdsworth DW, Drangova M, Dixon SJ, Séguin CA and Hammond JR. (2013) Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans. J. Bone Miner. Res. 28: 1135-49 [PMID:23184610]
- Yao SY, Ng AM, Cass CE, Baldwin SA and Young JD. (2011) Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1). J. Biol. Chem. 286: 32552-62 [PMID:21795683]
- Zhou M, Xia L and Wang J. (2007) Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine. Drug Metab. Dispos. 35: 1956-62 [PMID:17600084]